Helpful eaters: macrophages

You have opted for a Gold implant on a painful joint? You are well informed about how the millimetre-sized small fine gold pins are used in your case. Now you are probably wondering what causes these mini gold pins on your joint to give you the Pain and Inflammation in part or in full?

What does the gold do in these places? How can it be helpful? These are pertinent questions that have already been addressed by a number of scientists. The truth is that there are scientific ideas about the exact mode of action of gold pens and some studies that confirm these ideas and observations.

Several studies on the effect of gold

In a first study on gold implantation (2002), Prof Gorm Danscher (former Professor of Neurobiology at the University of Aarhus) clearly demonstrated that Gold ions from Gold implants and by the surrounding cells such as macrophages, Mast cells and Fibroblasts are „eaten“, so to speak. There they reduce excessive inflammatory reactions.

Further studies followed (2008 - 2012) and researchers now assume that the macrophages dock onto the gold implants and release gold ions from the fine implants. These are then released by the macrophages and Granulocytes and processed in teamwork. Prof Danscher observed that the large phagocytes inhibit inflammatory reactions and reduce tissue swelling (Oedema), which are triggered by mast cells, can be suppressed by their activity. They eliminate the swelling and relieve the pain.

First line of defence against pathogens: macrophages

Phagocytes ensure that fewer inflammatory messengers are activated in the tissue and they appear to boost the immune system. There are several types and one of them is the Macrophages, which translates as „big eaters“. Another type is called fibroblasts and both belong to the „Phagocytes“, the white blood cells (leukocytes) that are vital for defence against pathogens. They have the ability to absorb particles, microorganisms and fluids and digest them inside the cell. Phagocytes play an important role in our body's immune response. These hard-working helpers are already on the scene at birth to ward off disaster: They are part of the non-specific, innate immune system, which also has another division called the „specific, acquired immune system“.

Hard-working helpers

Pathogens are constantly invading our bodies. Almost all of them go unnoticed by our immune system. Macrophages are clever and constantly patrol the blood. They recognise hostile viruses or bacteria on their surfaces. They eat them up and the remnants of the enemies are released as messenger substances for their colleagues Granulocytes, that rush to the rescue. These are phagocytes that destroy the remains of the pathogens with poison.

These cells enclose the pathogens and „digest“ them. Remains of the pathogens migrate to the surface of the phagocytes and are quickly recognised by the acquired defence system (specific immune system, helper cells).

In addition to the phagocytes, there are other defence cells. These release substances that kill bacteria and other pathogens. In the course of the defence reaction, the pathogens as well as tissue and defence cells die and disintegrate.

Research continues

Have your questions been answered? Scientific research is still ongoing in 2020. And it will be interesting to see what else researchers find out in studies on the effect of gold implants and the role of macrophages!

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